Business Trip

Virtual Mitochondrial Models and the Case for Engineering Humans with Mariëlle van Kooten

Greg Kubin & Matias Serebrinsky Season 1 Episode 75

Use Left/Right to seek, Home/End to jump to start or end. Hold shift to jump forward or backward.

0:00 | 24:23

Mariëlle van Kooten (CEO and co-founder of Powerhouse Biology) joins to make the case that mitochondria are the best place to start engineering the human body. Her team builds virtual mitochondria models to predict how a fix will behave before it ever touches a patient. Marielle is passionate about treating disease and human enhancement. 

In this episode, we discuss:

  • Why mitochondria might be the most tractable place to start engineering human biology
  • The difference between building a virtual mitochondria model and the industry-wide race to build a virtual cell
  • Why a protein fix for one disease (say, Parkinson's-linked muscle weakness) could work across totally unrelated tissues
  • The difference between Science vs. Engineering: why she left academia
  • The case for human enhancement: longevity, resilience, and why the ethics conversation is stalled

Credits:

Created by Greg Kubin and Matias Serebrinsky
Host: Matias and Greg
Produced by Nico V. Rey
Find us at businesstrip.fm and psymed.ventures
Follow us on Instagram and Twitter!
Theme music by Dorian Love
Additional Music: Distant Daze by Zack Frank